CAS:150417-90-6丨GC7Sulfate
Sameindaformúla: C8H22N4O4S
Mólþyngd: 270,35
Hreinleiki: 98 prósent
Pakki:{{0}}.1g 0.25g 1g 5g 10g 25g
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ThetreatmentofMYCN2(±Dox)andBE(2)-CcellswithGC7Sulfatefor72hatvariousconcentrations(0.1to100μM)significantlyreducesthenumberofviablecellsinadose-dependentmanner.InMYCN2cells,5μMofGC7Sulfateinhibitscellviabilityby~40and~60 percent ,respectively,comparetountreatedcontrolcells.BE(2)-Ccellsrequire25μMofGC7Sulfatetoreducecellviabilityby~ 50 percent .Exposureto10and100μMGC7for72hclearlydecreasesthelevelsoftotalretinoblastoma(Rb)andphosphorylatedRbaswellasofCdk4prChemicalbookotein,andincreasesthelevelsofp21protein.Between0and20μM,GC7SulfateinduceslittlecytotoxicityinHCCcells,whilehigherconcentrationsofGC7Sulfate(50to100μM)significantlyinhibittheviabilityofallfiveHCCcelllinestested.Newlysynthesized3H-labeledhypusineofeIF5A1/eIF5A2israrelydetectedafter20μMGC7Sulfatetreatment,comparetountreatedcontrol.Theactivityof[3H]-spermidineincorporatedintoHCCcellsissignificantlydecreasedby20μMGC7Sulfateorhigherconcentration.
CAS:150417-90-6
Forskrift
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HLUTIR |
FORSKIPTI |
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CAS |
150417-90-6 |
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Hreinleiki |
98 prósent |
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